 Spilanthes acmella is a genus of plants that have major potential as a potent medicine, an all natural aphrodisiac and extremely effective anti-aging tool. In this post, we will discuss our most favorite plant, Paracress, the benefits of its bioactive components, and which products we currently offer. (R = reference) PLANT BASICS: Plants belonging to genus Acmella are called Spilanthes and there are over 30 species with the most common species used in Africa and India. R Traditionally, spilanthes has been used for treatment of toothache, stomatitis, throat complaints, malaria, soreness, dysentery, and gum care. R The major bioactive compounds, spilanthol (affinin) and alkylamides are found in: R
Other bioactive activities of Spilanthes are attributed to multiple bioactive compounds, N-isobutylamides, phenolic compounds, coumarins, and triterpenoids. R  BENEFITS OF PARACRESS (Spilanthes acmella) 1) Combats Skin Aging In Spilanthes acmella, spilanthol is responsible for anti-aging effects while trans-ferulic acid possess antioxidant activity. R In combination with certain botanicals, Spilanthes has an anti-aging effect on the skin. R More specifically, our products containing BiOlera (special blend of botanicals) stimulate the synthesis of type I collagen in fibroblasts and decrease the degradation of collagen, accelerates the collagen synthesis, and exerts potent inhibitory activity against fibroblast elastases. Spilanothol can penetrate the skin. R R Spilanothol has anti-inflammatory effects on the skin (by suppressing COX-2) by reducing expression of inflammatory cytokines (such as IL-6, IL-8, MCP-1, ICAM-1) and increasing Heme Oxygenase (HO‑1). R 2) Has Antimicrobial Properties Spilanthes has antibacterial effects against:
Spilanthes is able to reduce HIV/AIDS replication. R Spilanthes has insecticidal/pesticidal properties against:
Spilanthes may be toxic to some shellfish:  3) Increases Urine Output and Water Intake Spilanthes can act on the kidneys as a diuretic and can increase urine/salt excretion (increases urine Na+, K+ and a reduces osmolarity). R R Spilanthes may also help increase water intake. R Spilanthol can also significantly increase salivary output - for example, saliva flow increased 440% over baseline with use of a flavored toothpick and 628% over baseline with similarly flavored toothpicks infused with spilanthol. R 4) Enhances Oral Health Spilanthes has bioactivity on oral health. R For example, spilanthes (as well as Black Garlic, Black Seed Oil ((Nigella Sativa), and Propolis) can protect the microbiome in the mouth from dysbiosis caused by bad bacteria and fungi. R Spilanthes can also be used to reduce oral candida (thrush). R Spilanthes can also be used in films for reducing oral pain. R 5) Protects The Brain Spilanthes is neuroprotective against pesticide-induced neuronal death (by stabilizing calcium induced excitotoxicity and improving dopamine release). R Spilanthes can provide neuroprotection from oxidative stress by upregulating Sirtuin-1 (SIRT1) and Forkhead Box O3a (FOXO3A) as well as Superoxide Dismutase 2 (SOD2), Catalase, and B-Cell Lymphoma 2 (Bcl-2) proteins. R N-Alkylamides (NAAs) from Spilanthes can cross the gut barrier and are easily absorbed into the brain through the blood-brain barrier once it reaches the blood. R R R Spilanthes also contains beta-caryophyllene which has major neuroprotective properties by acting on the endocannabinoid system.- R Spilanthol (from heliopsis) may produce a stimulating effect similar to caffeine. R 6) Combats Ulcers In The Gut Spilanthes may help protect against alcohol-induced ulcers. R For example, in animals spilanthes can accelerate healing of ulcers by increasing of cellular proliferation and gastric mucus content, but reducing oxidative stress and inflammation. R Spilanthes in animal models is also very effective at combating ulcerative colitis. R 7) Fights Pain Extracts of spilanthes and heliopsis have been to create powerful anesthetics for combating pain. R R R Spilanthol can counteract pain by acting on opiodergic, serotoninergic, and GABAergic systems, as well as the NO/cGMP/K channel pathway and TRPV1/TRPA1 receptors. R R R For example, heliopsis can produce intense numbness and a tingling sensation in the lips, tongue and mouth. R Spilanthes can also produce this numbing/tingling effect. R N‑Alkylamides can work on the endocannabinoid system, bind to CB1 receptors, inhibit Fatty Acid Amide Hydrolase (FAAH), and inhibit of anandamide cellular uptake. R Some of spilanthes' pain reducing effects can be attributed to it's antihistamine effects as well. R 8) Quenches Inflammation Spilanthol has major anti-inflammatory effects. R R For example, spilanthes can inhibit macrophage activation from Lipopolysaccharide (LPS)-induced inflammatory responses - reduces inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), NF-kb, IL-1beta, IL-6, and TNF-alpha. R 9) Promotes A Healthy Vascular System  SOURCE: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5297847/ Spilanthes (as well as Spilanthol from Heliopsis) protects the vascular system as it increases antioxidant levels in the heart and can act as a vasorelaxant (acts as a vasodilator via NO/cGMP, CO/cGMP, H2S/KATP, and PGI2/cAMP). R R Spilanthes may also help prevent thrombosis. R 10) Improves Lung Function Spilanthes can combat fungi that contribute to Tuberculosis (TB), coughs, and sore throats. R R Spilanthes can also reduce inflammation in the lungs by suppressing COX-2 and ICAM-1 expression. R Spilanthes can also boost the antioxidant levels in the lungs by activating NRF2. R 11) Has Antioxidant Properties Bioactive compound in spilanthes (such as their flavonoids) are potent free radical scavengers. R R By reducing oxidative stress, spilanthes may help protect against carcinogen-induced DNA damage. R 12) Improves Wound Healing  SOURCE: Olera.de - Balms and lotions made with Paracress to increase wound healing. Spilanthol and α-Humulene can increase levels of collagen deposition in wounds. R
Spilanthes also has anesthetic properties (time ~83.6 (±28.5) min) making it useful for skin wounds, pressure sore, and infected surgical wounds treatment. R 13) Enhances Libido And Sex Behavior Spilanthens is a popular female aphrodisiac and can influence the estrous cycle without altering folliculogenesis and fertility. R For example in female animal models, splianthes can increase the frequency of the Proestrous (P) and Estrous (E) phase, while reducing the metaestrous (M) and diestrous (D) phases. R In male animal models, N-alkylamides acted similarly to Sildeafinil (Viagra). R In this study, N-alkylamides increased mounting frequency, intromission frequency and ejaculation frequency, as well as sex hormones Follicule Stimulating Hormone (FSH), Luteinizing Hormone (LH) and Testosterone (T). R In Uganda, spilanthes has been used traditionally to induce labor. R 14) Improves Metabolic Disease Spilanthes may help with parasite-induced metabolic disease. R For example, in animal models, spilanthes can restore abnormal lipid levels caused by Plasmodium berghei infection - reduced plasma level Total Cholesterol (TC), Triacylglycerol and Low Density Lipoprotein Cholesterol (LDL-C) and increased High Density Lipoprotein Cholesterol (HDL-C). R 15) Combats Diabetes Spilanthes may be useful as an antidiabetic as it can protect against high blood sugar levels (hyperglycemia) by normalizing blood sugar. R Spilathenes can normalize other markers of diabetes, such as MDA, AST, ALT, and creatinine levels, while increasing glutathione and TAOS. R 16) Fights Cancer Spilanthes may have anti-cancer effects on: Spilanthes can also reduce DNA damage and mutations from the consumption of Polycyclic Aromatic Hydrocarbons (PAHs).
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